03 October 2018

Publication: Extrapolation of praziquantel pharmacokinetics to a pediatric population

In September 2018, members of the Pediatric Praziquantel Consortium published a paper on the extrapolation of praziquantel pharmacokinetics to a pediatric patient population in the peer-reviewed Journal of Pharmacokinetics and Pharmacodynamics.

In September 2018, members of the Pediatric Praziquantel Consortium published a paper on the extrapolation of praziquantel pharmacokinetics to a pediatric patient population in the peer-reviewed Journal of Pharmacokinetics and Pharmacodynamics.
The article discusses how caution is advised when extrapolating praziquantel pharmacokinetics from healthy adults to infected patients of 2-5 years of age. Important factors to consider in extrapolation models seem to be differences in meal composition between the standardized Phase I unit and clinical sites in Africa, and differences in study population composition.
Many studies do not account for, or report on, the abovementioned differences, while this study shows they could greatly affect predicted exposure: simulated exposures were about tenfold lower compared to the clinical study results.
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